Luteal Phase Deficiency: Pathophysiology, Diagnosis & Treatment

Luteal Phase Deficiency

Luteal phase deficiency is one of the major areas of discussion in relation to finding out the causes of infertility. When Luteal phase occurs in women, normal functioning of the incubator in the body gets severely restricted. The process involves not only the egg, but it also interferes with the fetal journey from the ovary to the uterus. Luteal phase deficiency concerns the lack of synthesis of the endometrial covering of the uterus. Read up the rest of this article to bone up authentic information on Luteal phase defect and related issues.

Before elaborating further on Luteal phase deficiency, let’s form a basic idea about Luteal phase. Before ovulation takes place, the pituitary gland synthesizes and discharges luteinizing hormone (LH). This hormone, along with follicle-stimulating hormone (FSH), acts as a stimulant for the ovaries to synthesize estrogen and let the controlling follicle to release a developed egg. Note that the dominant follicle caves in as soon as the egg is released. The foundered follicle becomes a yellow mass of body known as corpus luteum.

The ovary is primarily composed of two cell categories: thecal cells and granulosa cells. The Luteal phase is named after the luteinized cells that originate out of the structural metamorphosis of the crumbled core of follicles. When this phase occurs during the reproductive cycle, the thecal and granulosa cells synthesize progesterone. This hormone plays the most important part in the nidation of the egg after fertilization and ovulation.

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The secretion of relaxin, 17-hydroxyprogesterone and inhibin from the ovary occurs in the interim period. Apart from these three hormones, a few other hormones are released as well during this phase. The estrogen levels increase to quicken up the development of the embryo placed inside the controlling follicle. This procedure occurs during the multiplication stage of fertilization. Progesterone receptors are developed as a result of the thickening of endometrium due to estrogen elevation. All these chemical steps are worth considering as far as Luteal phase deficiency is concerned. The synthesis of progesterone is activated by the corpus luteum.

Tracing the causes of Luteal phase deficiency is an intriguing clinical venture. Ideally this phase should be there for a minimum period of twelve to fourteen days. But when Luteal phase deficiency occurs, the longevity declines, creating an unfavorable setup for successful nidation of the embryo.

Fertile Soul Method has been accepted worldwide as the most reliable means for the treatment of Luteal Phase deficiency.